离子通道应用报告|欧罗拉

新兴应用

导电膜蛋白质在结构和功能上都是多样的。这种异质性是至关重要的服务范围广泛的生理作用。Aurora的ICR分析满足客户的需求，真诚地努力走在前沿，开拓解决具有挑战性问题的新途径。我们的科学家目前正在与制药和学术合作伙伴合作，开发新的和有效的基于ICR的分析方法，用于转运蛋白、天然化合物和癌症标志物的研究。

应用方向	文献名称	来源
Large Conductance Ca²⁺– Activated K⁺ Channels	Functional Analysis of Large Conductance Ca²⁺ -Activated K⁺ Channels: Ion Flux Studies	Abbott Laboratories
TRP Channels	Rb⁺ efflux assay for assessment of non-selective cation channel activities	Wyeth Research
Potassium Channels	Potassium Channels Methods and Protocols	SPRINGER
K_ATP channels	Structure of an open K_ATP channel reveals tandem PIP₂ binding sites mediating the Kir6.2 and SUR1 regulatory interface	Oregon Health & Science University
hERG¹ and Kv1.3 Potassium Channels	High throughput clone screening on overexpressed hERG¹ and Kv1.3 potassium channels using ion channel reader (ICR) label free technology	University of Florence
NKCC1	Validation of A Robust Label Free Screening Assay for NKCC1 Cotransporter	Aurora 集团
hERG	Design synthesis and biological evaluation of low-toxic lappaconitine derivatives as potential analgesics	西南交通大学
Calcium-Activated Chloride Channel	Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells	河北医科大学
Cation-Chloride Co-transporter	Development of Rubidium Flux Assay & HTS Campaign for Modulators of a Cation-Chloride Co-transporter	Roche
Na⁺,K⁺,-ATPase	Development of an HTS Assay for Na⁺,K⁺,-ATPase Using Nonradioactive Rubidium Ion Uptake	河北医科大学
hERG	Evaluation of the Rubidium Efflux Assay for Preclinical Identification of hERG Blockade	Pfizer
hERG	Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K⁺ channel	Merck
hERG	Characterization of a hERG Screen Using the IonWorks HT: Comparison to a hERG Rubidium Efflux Screen	Schering-Plough Research Institute
KCNQ2/3	Validation of Rubidium Ion Efflux Assay for KCNQ/M-Channels Using the Ion Channel Reader 8000	Wyeth Research
KCNQ2	A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux	AstraZeneca
Nav1.7	Cellular HTS Assays for Pharmacological Characterization of NaV 1.7 Modulators	AstraZeneca
TRPV1	Novel Methodology to Identify TRPV1 Antagonists Independent of Capsaicin Activation	AstraZeneca
Kir6.2	Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells	University of British Columbia
Na⁺-K⁺-Cl^– (NKCC1) cotransporter	Blockade of cell volume regulatory protein NKCC1 increases TMZ-induced glioma apoptosis and reduces astrogliosis	University of Pittsburgh Medical Center
Kv10.1 通道	Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma	河北工业大学和河北医科大学
离子通道	A High Throughput Screening Technology-Overcoming Bottlenecks in Ion Channel Drug Targets	Aurora集团
hERG	Rb+ Flux through hERG Channels Affects the Potency of Channel Blocking Drugs: Correlation with Data Obtained Using a High-Throughput Rb+ Efflux Assay	The Society for Biomolecular Screening
离子流与离子通道	Ion Channel Screening	Aurora集团
Rb-ion-efflux-assay	Nonradioactive Rubidium Ion Efflux Assay and Its Applications in Drug Discovery and Development	Discovery Research, Siena, Italy
离子通道	High Throughput Assay Technologies for Ion Channel Drug Discovery	Merck Research Laboratories
离子流	Ion Flux and Ligand Binding Assays for Analysis of Ion Channels	WILEY-VCH Verlag GmbH & Co
KCNQ	Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants	Johns Hopkins University
离子通道	Ion Channels: Targets Of High-Tech Screens	Biocompare
Kv1.5	High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5	Merck Research Laboratories
Kv1.3	High-Throughput Screening for Kv1.3 Channel Blockers Using an Improved FLIPR-Based Membrane-Potential Assay	Journal of Biomolecular Screening
TRP通道	18 In Vitro and in Vivo Assays for the Discovery of Analgesic Drugs Targeting TRP Channels	Taylor and Francis Group
离子通道	2011 Label Free Tech for DD Chap 8 Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels	University of Siena
钾离子通道	2012 The Antipsychotic Drug Loxapine Is an Opener of the Sodium Activated Potassium Channel Slack	Aurora集团
Slide Helix	Decomposition of Slide Helix Contributions to ATP-dependent	University of British Columbia
p.R1419H-ABCC8	Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8	University of British Columbia
NKCC1	A High-Throughput Screening Assay for NKCC1 Cotransporter Using Nonradioactive Rubidium Flux Technology	Aurora集团
KCNQ	Sequence Determinants of subtype-specific actions of KCNQ channel openers	University of Alberta
Kv7	Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy	河北医科大学
NKCC1	Role of NKCC1 Activity in Glioma K⁺ Homeostasis and Cell Growth New Insights With the Bumetanide-Derivative STS66	University of Pittsburgh
Na⁺,K⁺,-ATPase	Validation of Rb Uptake Assay	Aurora集团
离子通道	Screening Technologies for ion channel drug discovery	Future Science

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